The Centella asiatica active Asiaticoside eliminates free radical damage in blood vessels
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Asiaticoside from Gotu Kola prevents oxidative damage and reverses all markers of oxidation in endothelial cells
In addition, asiaticoside partially reverses cell senescence
Asiaticoside in cellulite creams and nutritional supplements
Asiaticoside Prevents Oxidative Stress and Apoptosis in Endothelial Cells by Activating ROS-dependent p53/Bcl-2/Caspase-3 Signaling Pathway
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Asiaticoside from Gotu Kola prevents oxidative damage and reverses all markers of oxidation in endothelial cells
Asiaticoside and the other three centella asiatica main active molecules (asiatic acid, madecassic acid, asiaticoside and madecassoside) are known for their multiple action against whole body ageing, skin ageing and cellulite.
In this new study of human umbilical vein endothelial cells (HUVECs), asiaticoside was found to reverse all markers of oxidative stress.
Furthermore, asiaticoside restored antioxidant markers, such as SOD (superoxide dismutase), NO (nitric oxide) and GSH-Px (glutathione peroxidase), after oxidative insult.
In addition, asiaticoside partially reverses cell senescence
Plus asiaticoside significantly reversed senescence-associated beta-galactosidase (SA-β-gal) activity, a marker of cell senescence. (Senescence is a major cause of ageing and whole body inflammation - and consequently cellulite.)
Given its anti-senescence properties, asiaticoside can be used as part of anti-senescence / senolytic regime for blood vessels and entire body.
Asiaticoside in cellulite creams and nutritional supplements
Cellular senescence is an important aspect of cellulite, especially senescence of blood vessels, skin and adipose tissue. Asiaticoside, and most probably the other three gotu kola triterpenes too, help reverse senescence.
Furthermore, gotu kola helps fight cellulite via multiple other pathways, including fibrosis, inflammation, glycation and oxidative stress reduction.
So the anti-senescence action of asiaticoside, adds yet another way in which gotu kola / centella asiatica helps prevent / reduce cellulite.
Asiaticoside can be found in:
Proper, therapeutic concentrations in a very small number of quality anti-cellulite and anti-aging creams (most are very diluted and/or contain low purity active ingredients)
A small number of quality centella asiatica / gotu kola nutritional supplements (difficult to source and most are not concentrated enough)
Centella asiatica herbal tea (easy to source on the internet these days)
Asiaticoside Prevents Oxidative Stress and Apoptosis in Endothelial Cells by Activating ROS-dependent p53/Bcl-2/Caspase-3 Signaling Pathway
Abstract: Background: Asiaticoside (AC) is a triterpenoid saponin found in Centella asiatica (L.) Urban extract that has a wide range of pharmacological properties. Our previous study demonstrated that AC could promote angiogenesis in diabetic wounds, but the specific mechanisms remain unknown. Objective: This study aimed to examine the effectiveness and mechanism of AC on human umbilical vein endothelial cells (HUVECs) exposed to tert-butyl hydroperoxide (t-BHP) toxicity. Methods: Senescence was confirmed using senescence-associated beta-galactosidase (SA-β-gal) activity and expression of the cell cycle phase markers p16 and p21. The levels of SOD, NO, MDA, GSH-Px, ROS were tested. Furthermore, several cell death-related genes and proteins (p53, Bax, Bcl-2 and Caspase-3) were assessed with RT-qPCR and Western blotting. Results: AC significantly reduced SA-β-gal activity, with both the suppression of cell-cycle inhibitors p16 and p21. We also found that the induced oxidative stress and apoptosis caused by t-BHP treatment resulted in the decrease of antioxidant en-zymes activities, the surge of ROS and MDA, the up-regulation of p53, Bax and caspase-3, and the decrease of SOD, NO, GSH-Px and Bcl-2. These biochemical changes were all reversed by treatment with varied doses of AC. Conclusion: AC alleviates t-BHP-induced oxidative injury and apoptosis in HUVECs through the ROS-dependent p53/Bcl-2/Caspase-3 signaling pathway. It may be a potential antioxidant applied in metabolic disorders and pharmaceutical products.
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At LipoTherapeia we have specialised 100% in skin tightening and cellulite reduction for more than two decades and 20,000+ sessions.
This is all we study and practise every day and have researched and tried hands-on all the important skin tightening equipment and their manufacturers.
As strong, deep acting radiofrequency and deep-acting, high-power ultrasound cavitation are the technologies of choice for skin tightening and cellulite reduction, we have invested in the best RF/ultrasound technologies in the world.
Furthermore, over the last two decades we have developed advanced RF and cavitation treatment protocols in order to make the most of our technologies, for maximum results, naturally and safely.
And for even better, faster results, we now combine our RF/ultrasound treatments with high-power red/infrared light LED treatment.
Our radiofrequency/ultrasound/LED treatments are comfortable, pain-free, downtime-free, injection-free, microneedling-free, 99.5%+ safe and always non-invasive.
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We will be pleased to see you, assess your cellulite, skin laxity or fibrosis, listen to your story, discuss your case and offer you the best possible treatment.
Advanced, infrared / blue / red light therapy treatments in London at LipoTherapeia
At LipoTherapeia we are passionate about phototherapy (also known as photobiomodulation/PBM, red light therapy, infrared light therapy, blue light therapy, LED light therapy etc) and we use the most powerful equipment available today (up to 200mW/cm2), for best results and treatment of large body areas.
We use specialised therapy protocols for skin rejuvenation / anti-ageing, pigmentation / post-inflammatory hyperpigmentation (PIH), moderate/severe acne, skin redness, sensitive/inflamed/irritated skin, wound healing, sports injuries / musculoskeletal pain and overall wellness / well-being.
Our LED phototherapy sessions are comfortable, deeply relaxing and super-safe and are great to enhance our radiofrequency/ultrasound treatments for skin tightening / cellulite reduction.
On our booking page you can book stand-alone phototherapy sessions or combine them with our other treatments, as an add-on.
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