Cigarette smoking and high temperature cooking of carbohydrates and fats leads to the creation of various chemicals detrimental to health, two of them being glyoxal and methylglyoxal (MGO). These chemicals eventually lead to the creation of Advanced Glycation End-products (AGEs), which cause whole body ageing, whole body and facial skin ageing and cellulite…
Cellular senescence, skin ageing and cellulite
Cellular senescence, literally meaning “cell aging”, is the process by which cells stop dividing and enter a senile stage characterised by dysfunction and the spreading of inflammation. Cellular senescence leads to the production of pro-inflammatory mediators that can spread inflammation to thousands of other cells in the vicinity of a group of senescent cells or even throughout the body. Cells normally enter cellular senescence after approximately 50 cell divisions (mitoses) and this normal process is known as "replicative senescence". When a cell enters senescence it is selected to be cleared by the immune system, in a process called senolysis…