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How can I lose (almost) all of my body fat, permanently?

How can I lose (almost) all of my body fat, permanently?

This is something we hear often: “I wish there was something, a pill or a procedure, to kill (almost) all my fat cells forever, so I can eat whatever I want and never put on weight anymore”. Most people actually use the word “almost” to mean that some fat should stay intact in all the strategic places (butt, breasts, face etc), with the rest mostly gone. To which my answer is: “Be careful what you wish for…” Because, believe me, you would not want such a thing to happen to you, as without fat cells you would end up dead. Let me explain.