Chronic venous insufficiency (CVI) is common in women, especially older or overweight women. Common symptoms include fat accumulation under/inside the skin, oedema (water retention), heavy legs, muscle cramps, pain and varicose veins. Several natural supplements are used for CVI which can help relieve symptoms of the condition, including centella asiatica/gotu kola extract, hesperidin, diosmin, butcher’s broom extract and escin/horse chestnut extract and red vine leaf extract among others.